Network Pharmacology Prediction to Explore the Potential Mechanism of Qing'E Pills

Qing’E pills are a classical formula in traditional Chinese medicine that has the effect of tonifying kidneys and strengthening bones, first appearing tonic formulae prescriptions peaceful benevolent dispensary (10th century CE). To preliminarily elucidate potential mechanisms treatment postmenopausal osteoporosis based on network pharmacology. The principal components corresponding protein targets were searched systems pharmacology, bioinformatics analysis tool for molecular mechanism-traditional medicine, SymMap encyclopedia compound-target was constructed by Cytoscape 3.9.1. online mendelian inheritance man, GeneCards, histidine triad nucleotide binding DisGeNET databases. intersection compound target disease obtained coincidence imported into search retrieval interacting genes database to construct protein-protein interaction network. We further performed gene ontology Kyoto genomes enrichment analyses targets. 33 active compounds corresponded 433 1647 associated with disease. high degree values quercetin, stearic acid marine. proteins higher mitogenactivated kinase 1, B, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, phosphoinositide-3-kinase regulatory amyloid beta precursor protein, Src proto-oncogene, nonreceptor tyrosine kinase, mitogen-activated 8, heat shock 90 alpha family class A member epidermal growth factor receptor, Janus 2. Gene showed involves signaling pathways mainly include tumor necrosis pathway, osteoclast differentiation, Wnt pathway estrogen pathway. revealed ingredients mechanism provided reference subsequent basic research